Cash drawers are typically paired with a receipt printer rather than connected to the computer on their own.
There are different cash drawer configurations and cash drawer cables, so the drawer has to be compatible with the printer it's paired with.
We do not work with USB cash drawers. Every receipt printer we support opens the cash drawer through a cash drawer cable: when a receipt prints, that signal is what releases the drawer, rather than the computer communicating with the drawer over USB.
For setup steps, see Cash Drawer Configuration.